Inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis in the rat by the retinoid axerophthene

Thompson, H.J.; Becci, P.J.; Moon, R.C.; Sporn, M.B.; Newton, D.L.; Brown, C.C.; Nürrenbach, A.; Paust, J.; Thompson, H.J; Becci, P.J; Moon, R.C; Sporn, M.B; Newton, D.L; Brown, C.C; Nürrenbach, A; Paust, J

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Inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis in the rat by the retinoid axerophthene

Thompson, H.J.; Becci, P.J.; Moon, R.C.; Sporn, M.B.; Newton, D.L.; Brown, C.C.; Nürrenbach, A.; Paust, J.

Arzneimittel-Forschung 30(7): 1127-1129

1980

ISSN/ISBN: 0004-4172

PMID: 7191293

Document Number: 166412

The hydrocarbon retinoid, axerophthene, and retinyl acetate were compared for their ability to prevent mammary cancer induced in rats by 1-methyl-1-nitrosourea. Chronic feeding of both retinoids delayed the appearance and lessened the incidence of cancers; retinyl acetate was definitely more active. However, axerophthene was significantly better tolerated by the rats and allowed normal weight gain when fed in high doses, in contrast to retinyl acetate.