Protective effects of 3, 6-dimethamidodibenzopyriodinium citrate on myocardial injury induced by ischemia and reperfusion in rats
Deng, X.L.; Qiu, P.L.; Liu, J.T.; Chen, S.Y.
Zhongguo Yao Li Xue Bao 14(4): 367-369
1993
ISSN/ISBN: 0253-9756 PMID: 8249638 Document Number: 406581
3,6-Dimethamidodibenzopyriodonium citrate (I-65) 0.5 and 1 mg cntdot kg-1 pretreatment reduced the size of myocardial infarct after ischemia for 40 min and reperfusion for 120 min. I-65 0.5 mg cntdot kg-1 decreased myocardial creatine kinase, lactate dehydrogenase release, and Ca-2+ accumulation after ischemia for 40 min and reperfusion for 120 min. The results show that I-65 prevents cardiac ischemia and reperfusion injury and the effect is considered to be related to inhibition of myocardial Ca-2+ accumulation.