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Taking the 20-HETE out of the cardiovascular system: the potential of 20-HETE synthesis inhibitors

Doggrell, S.A.

Current Opinion in Investigational Drugs 6(9): 901-906

2005

ISSN/ISBN: 1472-4472
PMID: 16187690
Document Number: 593709
In addition to being metabolized by cyclooxygenase and lipooxygenase to prostaglandins and leukotrienes, arachidonic acid can be metabolized to 20-hydroxyeicosatetraenoic acid (20-HETE) by cytochrome P450 enzymes omega-hydroxylases. As 20-HETE has both pro-hypertensive and antihypertensive actions, inhibitors of 20-HETE synthase may not be useful as antihypertensives in all forms of hypertension. However, 20-HETE synthase inhibitors can have cardioprotective and cerebroprotective effects in animal models, and can inhibit angiogenesis; therefore they may have clinical potential in these areas.

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