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Universal modular system for in vitro screening of potential inhibitors of HIV-1 replication

Prokof'eva, M.M.; Orlova, N.N.; Gornostaeva, A.S.; Shul'gin, A.A.; Nikitenko, N.A.; Senchenko, V.N.; Lebedev, T.D.; Spirin, P.V.; Riechen, K.; Fehse, B.; Stocking, C.; Prasolov, V.S.

Molekuliarnaia Biologiia 48(2): 344-348

2014

ISSN/ISBN: 0026-8984
PMID: 25850304
Document Number: 673598
Here we describe a system based on recombinant lentiviral vectors for the safe screening of potential anti-HIV drugs. The system allows to evaluate the sensitivity of HIVl-1 reverse transcriptase and integrase (wild-type as well as mutant forms of these enzymes detected in drug-resistant virus isolates) towards different drugs and substances, but also to screen inhibitors of other stages of HIV-1 life cycle.

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