Polymorphism of N-acetyltransferase-2 and pathogenesis of neoplastic diseases
Kłodowska-Duda, G.A.; Samelska, J.A.; Opala, G.M.
Wiadomosci Lekarskie 58(3-4): 212-217
2005
ISSN/ISBN: 0043-5147 PMID: 16119167 Document Number: 593117
Pathogenesis of many diseases is connected with influence of environmental factors with individual genetic sensitivity dependent among others on detoxification enzymes. Mutations of N-acetyltransferase-2 lead to decreased enzyme function. In this review the focus is on discussion about the connection between the polymorphic N-acetyltransferase-2 and increase in the risk of cancer, atopic disease and adverse drug effects.