Auxiliary value of TPA in diagnosing neoplastic diseases
Mizushima, Y.; Nakamura, F.; Yokoyama, A.; Morikage, T.; Kawasaki, S.; Hoshino, K.; Maruyama, M.; Yamashita, N.; Yano, S.
Gan no Rinsho. Japan Journal of Cancer Clinics 32(7): 779-782
1986
ISSN/ISBN: 0021-4949 PMID: 3735675 Document Number: 283211
The auxiliary value of TPA in diagnosing neoplastic diseases was compared to other tumor markers such as CEA, IAP and ferritin. The study population consisted of 59 patients with neoplastic diseases and 75 with benign diseases. The percentages of positive cases for TPA, CEA, IPA and ferritin were 58.9%, 39.0%, 66.7%, and 28.6% in neoplastic diseases and 4.5%, 1.4%, 47.1% and 19.7% in benign diseases, respectively. Both the specificity and sensitivity of TPA were as high as those of CEA. However, the positive rate of TPA was lower than that of CEA in lung cancer patients at stages I and II. TPA was indicated to be a suitable marker for combination assay with CEA in diagnosing neoplastic diseases.