Peculiarities of the temporal organization of the behavioral response to caffeine in rats
Eksperimental'naia i Klinicheskaia Farmakologiia 68(1): 10-12
2005
ISSN/ISBN: 0869-2092 PMID: 15786956 Document Number: 590022
Chronic administration of a standard dose of caffeine (40 mg/kg) facilitated the formation of more clear circadian mobility rhythm in rats. The test animals belonging to various chronotypes exhibited a significant difference in sensitivity with respect to this psychostimulant. Rats possessing a more pronounced rhythm organization showed a greater increase in the rhythm amplitude, with the acrophase more significantly shifted toward early night hours. It is suggested that the individual chronotype features have to be taken into account in experimental and clinical pharmacology.