Quo vadetis coxibs?
Grazio, S.; Anić, B.
Reumatizam 52(1): 17-27
2005
ISSN/ISBN: 0374-1338 PMID: 16689107 Document Number: 590023
After the withdrawall of rofecoxib from worldwide market, there is ongoing debate whether gastrointestinal safety of COX-2 inhibition compared to non-selective NSAID-s may come at the cost of increased cardiovascular events. In this paper the relevant data regarding mechanisms, effects and side effects of selected COX-2 inhibitors are presented. Possible class effect is disscused and proposed alternative therapies.