Peculiarities of the organism immune response in patients suffering ischemic cardiomyopathy
Vorob'eva, A.M.; Bespalova, E.I.; Balannik, Z.T.; Klimova, L.N.; Lisnichaia, V.N.; Rybakova, E.V.
Klinichna Khirurhiia 8: 31-33
2008
ISSN/ISBN: 0023-2130 PMID: 19145840 Document Number: 620235
Ischemic cardiomyopathy (ICMP) constitutes the organspecific systemic form of autoimmune pathology. Now existing hypotheses of the ICMP pathogenesis trust the multistaged course of the disease with concurrent changes in the cellular and humoral chains of immunity. Among the immune disorders there are interrelated chains, influencing the disease course severity. Dysfunction of T- and B-lymphocytes, natural cell-killers (EKK-CD16+), R-IL2 (CD25+), apoptosis (CD95+), pro- and antiinflammatory cytokines causes changes in myocardium contractility, occurrence of congestion events, chronic cardiac insufficiency.