Inhalation toxicity studies of methyl isocyanate (MIC) in rats: Part IV--Immunologic response of rats one week after exposure: effect on body and organ weights, phagocytic and DTH response
Dwivedi, P.D.; Mishra, A.; Gupta, G.S.; Dutta, K.K.; Das, S.N.; Ray, P.K.
Indian Journal of Experimental Biology 26(3): 191-194
1988
ISSN/ISBN: 0019-5189 PMID: 3397124 Document Number: 306979
Immunotoxicological evaluation of rats exposed to MIC was done on animals after 7 days of exposure to it. Initial and final body weights, percent organ weights and alveolar and peritoneal macrophage functions were evaluated. No increase in the body weight was found in treated animals after 1 week of exposure whereas percent thymus and liver weights were significantly enhanced. Both alveolar and peritoneal macrophage functions were significantly impaired in the exposed animals as compared to controls. Delayed type hypersensitivity, enumerated against sheep red blood cells was found significantly impaired in MIC exposed animals as compared to the controls.