Effect of phenazepam on the body organs and systems of rats subjected to prolonged ethanol exposure
Liubimov, B.I.; Sorokina, A.V.; Iavorskiĭ, A.N.; Krylova, A.M.; Boĭko, S.S.
Farmakologiia i Toksikologiia 46(1): 82-86
1983
ISSN/ISBN: 0014-8318 PMID: 6130972 Document Number: 200119
Experiments made on 80 randombred male rats have demonstrated that the tranquilizer phenazepam in a daily dose of 1 mg/kg administered per os to intact animals for 14 days produces no adverse changes in the hematological, biochemical and morphological indicators that characterize the status of the most important organs and systems of the body. Administration of phenazepam to rats preexposed to ethanol (4 g/kg per os once a day for a month) has been found to retard the elimination of morphological alterations in the liver and brain induced by ethanol. The results obtained allow recommending the use of appropriate experimental models in the preclinical study of the safety of new antialcoholic agents.