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Experimental study of the "'rebound syndrome" following discontinuation of prolonged phenazepam administration and possibilities for preventing it

Voronina, T.A.; Garibova, T.L.

Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 81(7): 1056-1059

1981

ISSN/ISBN: 0044-4588
PMID: 7197446
Document Number: 180933
Phenazepam given to rats in a daily dose of 2 mg/kg intraperitoneally for a long (30 days) time ceased to produce the sedative effect, and discontinuation of the medication led to development of the so-called "recoil syndrome" characterized by general depression and disturbances of the conditioned-reflex activity. The "recoil syndrome" was distinguished for a selective specificity, since its motor and sensor manifestations were eliminated only by benzodiazepine derivatives (phenazepam, diazepam). Drugs from other chemical slasses (meprobamate, trioxazine, amipazin) did not influence this syndrome.

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