Experimental pharmacokinetics of phenazepam during transdermal administration of the therapeutic phenaperkuten system
Litvin, A.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 67(2): 59-62
2004
ISSN/ISBN: 0869-2092 PMID: 15188765 Document Number: 576971
The pharmacokinetics of fenazepam upon application of the transdermal therapeutic system (TTS) fenapercuten in various forms and under different conditions was studied in rabbits. The rate of the transdermal transfer of fenazepam from TTS to blood varied from 0.76 to 2.89 mg/(ml cm2). It was found that the drug transfer rate remains constant for 2-3 days. After removal of the TTS, fenazepam is eliminated within 3 days.
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