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Effect of subacute exposure to methyl isocyanate on testicular histomorphology in mice

Arora, U.; Vijayaraghavan, R.

Indian Journal of Experimental Biology 27(4): 347-349

1989

ISSN/ISBN: 0019-5189
PMID: 2807414
Document Number: 341353
Mice exposed to methyl isocyanate (MIC; 134 mg.m-3 for 30 min = 4020 mg.min-1.m-3) showed a marked loss of body weight after 24 hr and the mean body weight of the exposed group was significantly less than the control, even 15 days after the exposure. No significant change was observed on relative testicular weight. Spermatozoa in the seminiferous tubules disappeared 3 days post exposure. Primary and secondary spermatocytes were hypertrophied. Normalization occurred after 15 days.

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