Effect of streptokinase on the parameters of haemostasis in model systems in vivo
Krasnobryzha, I.M.; Savchuk, O.M.; Volkov, H.L.
Ukrains'kyi Biokhimichnyi Zhurnal 76(3): 56-61
2004
ISSN/ISBN: 0372-3909 PMID: 19621739 Document Number: 584177
The changes of the haemostasis system parameters were studied under treatment by streptokinase (Sk, thrombolytic agent of bacterial origin) with the use of model systems in vivo. We were especially interested in the study of the changing fibrinolytic system parameters such as tissue type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), plasminogen, alpha2-antiplasmin activities. After treatment by Sk the activity and quantity of t-PA were significantly increased while the activity of PAI-1 was decreased. The parameters of haemostasis system evidenced for a disbalance which occurred under treatment by Sk: decrease of fibrinogen levels and appearance of soluble fibrin and accumulation of fibrin degradation products. Thus analysis of the data has displayed besides the well-known Sk function the influence of Sk on the change of fibrinolytic system potential probably due to its effect on the endothelial cells.