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Effect of desmopressin (DDAVP) on blood platelet parameters in vivo and in vitro

Kätzel, R.; Dietzel, H.; Selle, B.; Taube, C.

Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 47(7): 303-307

1992

ISSN/ISBN: 0044-2542
PMID: 1496839
Document Number: 402086
Coagulation assays including DDAVP test were carried out in 15 patients preoperatively, evaluating several parameters of platelets during the assays. After DDAVP infusion we observed a decreased spontaneous aggregation in whole blood, an increased retention to glass beads, and in a number of cases a raised in vitro-formation of thromboxane. By application of DDAVP, a significant enhancement of spontaneous aggregation in whole blood and left shift to smaller volumes of the platelet volume distribution were demonstrated in vitro. It is concluded that DDAVP has an indirect inducing effect on aggregation, probably by release of ADP from red blood cells.

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Chen, S.L.; Yang, W.C.; Huang, T.P.; Wann, S.A.; Teng, C.M. 1990: Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro Thrombosis and Haemostasis 64(3): 473-477
LoCicero, J.; Massad, M. 1990: Any value for desmopressin acetate (DDAVP) in cardiopulmonary bypass operation? Journal of Thoracic and Cardiovascular Surgery 99(5): 945
Cortellaro, M. 1972: Effect of S-adenosylmethionine (SAM) on platelet aggregation. In vitro and in vivo study Minerva Medica 63(32): 1854-1860
Groves, H.M.; Kinlough-Rathbone, R.L.; Cazenave, J.P.; Dejana, E.; Richardson, M.; Mustard, J.F. 1982: Effect of dipyridamole and prostacyclin on rabbit platelet adherence in vitro and in vivo Journal of Laboratory and Clinical Medicine 99(4): 548-558
Hara, H.; Tamao, Y.; Kikumoto, R.; Funahara, Y.; Hijikata, A.; Okamoto, S. 1980: Effect of a potent thrombin inhibitor, No. 407, on platelet function in vitro and in vivo Kobe Journal of Medical Sciences 26(1): 47-60
Chevolet, C.; Grosdent, J.C.; Reiters, G.M.; Dresse, A. 1982: Platelet aggregation measured in rabbit whole blood: in vitro study of 3 aggregating agents and ex vivo inhibition by aspirin and ticlopidine Archives Internationales de Pharmacodynamie et de Therapie 259(2): 310-311
Cattaneo, M.; Tenconi, P.M.; Alberca, I.; Garcia, V.V.; Mannucci, P.M. 1990: Subcutaneous desmopressin (DDAVP) shortens the prolonged bleeding time in patients with liver cirrhosis Thrombosis and Haemostasis 64(3): 358-360
Poveshchenko, A.F.; Kozlov, V.A. 1999: The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 53-56
Torlińska, T.; Grzymisławski, M.; Paluszak, J.; Sosnowski, P.; Torliński, L.; Koźlik, J. 1987: Triiodothyronine effect on some parameters of carbohydrate metabolism in rat blood and liver. I. in vivo effect of triiodothyronine on liver glycogen content, blood metabolites and serum glycogenolytic activity Acta Physiologica Polonica 38(4): 353-360
Ambrus, J.L.; Ambrus, C.M.; Gastpar, H.; Williams, P. 1982: Study of platelet aggregation in vivo. IX. Effect of nafazatrom on in vivo platelet aggregation and spontaneous tumor metastasis Journal of Medicine 13(1-2): 35-47
Pfueller, S.L.; Howard, M.A.; White, J.G.; Menon, C.; Berry, E.W. 1987: Shortening of bleeding time by 1-deamino-8-arginine vasopressin (DDAVP) in the absence of platelet von Willebrand factor in Gray platelet syndrome Thrombosis and Haemostasis 58(4): 1060-1063
Rao, A.K.; Ghosh, S.; Sun, L.; Yang, X.; Disa, J.; Pickens, P.; Polansky, M. 1995: Mechanisms of platelet dysfunction and response to DDAVP in patients with congenital platelet function defects. a double-blind placebo-controlled trial Thrombosis and Haemostasis 74(4): 1071-1078
Cattaneo, M.; Pareti, F.I.; Zighetti, M.; Lecchi, A.; Lombardi, R.; Mannucci, P.M. 1995: Platelet aggregation at high shear is impaired in patients with congenital defects of platelet secretion and is corrected by DDAVP: correlation with the bleeding time Journal of Laboratory and Clinical Medicine 125(4): 540-547
Szuster-Ciesielska, A.; Kamińska, T.; Kandefer-Szerszeń, M. 1995: Phagocytosis-enhancing effect of lactoferrin on bovine peripheral blood monocytes in vitro and in vivo Archivum Veterinarium Polonicum 35(1-2): 63-71
Van Vliet, H.H.D.M.; Kappers-Klunne, M.C.; Leebeek, F.W.G.; Michiels, J.J. 2008: PFA-100 monitoring of von Willebrand factor (VWF) responses to desmopressin (DDAVP) and factor VIII/VWF concentrate substitution in von Willebrand disease type 1 and 2 Thrombosis and Haemostasis 100(3): 462-468
Etienne, J.; Grüber, A.; Polonovski, J. 1976: In vivo activation of blood and arterial prophospholipase by an activator of blood platelet origin Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 170(6): 1159-1165
Babalola, C.P.; Oladimeji, F.A.; Femi-Oyewo, M.N. 2001: Correlation between in vitro and in vivo parameters of commercial paracetamol tablets African Journal of Medicine and Medical Sciences 30(4): 275-280
Pawłowska, D.; Koćmierska-Grodzka, D.; Moniuszko-Jakoniuk, J. 1987: The effect of methylbromophenvinfos (Polfos) on some enzymes in vivo and in vitro. I. In vivo studies Polish Journal of Pharmacology and Pharmacy 39(4): 361-370
Otsuka, Y.; Nagano, K.; Nagano, K.; Hori, K.; Oh-ishi, J.; Hayashi, H.; Watanabe, N.; Niitsu, Y. 1990: Inhibition of neutrophil migration by tumor necrosis factor. Ex vivo and in vivo studies in comparison with in vitro effect Journal of Immunology 145(8): 2639-2643
Tschopp, T.B.; Baumgartner, H.R. 1979: Platelet adhesion and aggregation in arteries of rats, rabbits and guinea pigs in vivo and in vitro correlate negatively with their prostacyclin (PG I2) production Agents and Actions. Supplements 4: 156-162