Studies on hydrogenation of aminonitriles. X. Catalytic hydrogenation of N,N-bis- (2-cyanoethyl) -amine and of its N-alkyl derivates
Mikolajewska, H.; Kotelko, A.
Acta Poloniae Pharmaceutica 23(5): 425-431
1966
ISSN/ISBN: 0001-6837 PMID: 5959388 Document Number: 5796
Bis-cyanoethyl derivatives of ammonia and of simple aliphatic amines have proved as good substrates for preparation of the derivatives of 1,5-diazacyclooctane. The employed conditions of the reductive cyclization consisted in application of appropriate amount of the Raney nickel catalyst W-2, temperature 180-200° and in the use of tertiary butyl alcohol as the solvent. Under these conditions, 1,5-diazacyclooctane was obtained 13% yield and its N-alkyl derivatives in the yield 28-38%. It has been also observed that the yield of the reductive cyclization is higher in cases of N -substituted N,N-bis-2-cyanoethyl-amines that corresponds the observations made during the studies on synthesis of homopiperazine.
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