The research on biotransformation of praziquantel
Godawska-Matysik, A.; Pekala, E.; Kieć-Kononowicz, K.
Acta Poloniae Pharmaceutica 61 Suppl: 75-78
2004
ISSN/ISBN: 0001-6837 PMID: 15909947 Document Number: 573885
Praziquantel (PZQ), a broad spectrum antihelmintic drug, is extensively metabolized in the liver, yielding mainly monohydroxylated and dihydroxylated phase-I-metabolites. However, the exact chemical structures of the most metabolites are still unknown. In the presented research, three types of PZQ biotransformations were performed: biotransformation with the whole cells of Saccharomyces cerevisiae, with cytochrome c from Saccharomyces cerevisiae and with microsomes isolated from Saccharomyces cerevisiae. To describe the obtained metabolites TLC, RP-TLC, and HPLC were used.