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A case of recurrent gastric cancer with malignant ascites responding dramatically to chemotherapy with paclitaxel infused systemically and intraperitoneally

Morifuji, M.; Murakami, Y.; Yokoyama, Y.; Sasaki, M.; Hayashidani, Y.; Toge, K.; Sueda, T.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 31(12): 2027-2030

2004

ISSN/ISBN: 0385-0684
PMID: 15570933
Document Number: 571726
We report a case in which chemotherapy with paclitaxel (TXL) infused systemically and intraperitoneally was effective for gastric cancer with malignant ascites. A 69-year-old man suffering from advanced gastric cancer with peritoneal dissemination underwent distal gastrectomy, a radical C operation. After chemotherapy with TS-1 and low-dose CDDP, TS-1 was administrated on an outpatient basis for 6 months. However, he complained of abdominal fullness and ascites, and received combination chemotherapy with paclitaxel infused systemically and intraperitoneally as second-line treatment. The ascites completely disappeared 5 weeks after administration. The only toxic event was anemia (grade 1), and no major adverse effects were observed.

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