A case of gastric cancer with peritoneal dissemination successfully treated by S-1/paclitaxel combination chemotherapy
Shoji, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 38(2): 297-300
2011
ISSN/ISBN: 0385-0684 PMID: 21368499 Document Number: 650026
A 62-year-old woman visited our hospital with diarrhea, bloating, vomiting, and black stool. Borrmann-type 3 gastric cancer with hemorrhaging was revealed by stomach endoscopy. The biopsy showed a poorly-differentiated adenocarcinoma. Moreover, peritoneal dissemination was found by computed tomography and we combined S-1 80 mg/m²(4 weeks administration and week rest)with paclitaxel(PTX)50 mg/ m² (day 1, 8, 15, 3 weeks rest). After 2 courses, endoscopy showed tumor shrinkage. Therefore, we conducted total gastrectomy with resection of gall bladder and spleen. The final findings were Stage II .We conducted S-1/PTX combination chemotherapy(4 courses)followed by monotherapy as adjuvant chemotherapy. Recently, the woman had been living without relapse four years after operation.