A case of gastric cancer with peritoneal dissemination and massive ascites successfully treated with S-1/docetaxel therapy
Iwakura, S.; Shimamoto, T.; Higashiguchi, T.; Nakase, T.; Shimada, K.; Kunimoto, H.; Aoki, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 39(8): 1251-1253
2012
ISSN/ISBN: 0385-0684 PMID: 22902452 Document Number: 662489
A 49-year-old woman who complained of abdominal bloating and numbness in the bilateral lower limbs was diagnosed as advanced scirrhous gastric cancer with massive ascites. The biopsy specimen showed a poorly-differentiated adenocarcinoma. She was therefore treated with combined chemotherapy of tri-weekly docetaxel(40mg/m2, day 1, 22)and S-1(60mg/m2, day 1-14 with 1-week rest)for unresectable gastric cancer. After 5 courses, computed tomography showed no ascites. Furthermore, after 31 courses, the loss of ascites continued, and the thickening of the stomach walls was reduced. These findings suggested that a complete response in terms of Evaluation Criteria in Solid Tumors(RECIST)was obtained. The side effects throughout chemotherapy were Grade I anemia and Grade I alopecia. Docetaxel and S-1 chemotherapy may well be one of the effective treatments for advanced scirrhous gastric cancer.