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Procarbacine radiolysis and experiments in vitro

Delipetar-Grudl, A.; Getoff, N.

Anticancer Research 24(3a): 1593-1596

2004

ISSN/ISBN: 0250-7005
PMID: 15274327
Document Number: 567449
Steady-state radiolysis of aqueous procarbazine (PC) was studied in air-free, aerated and solutions saturated with N2O. The corresponding Gi(-PC)-values obtained at pH=7.4 were: 2.85, 5.60 and 3.45, respectively. The investigations in vitro, using E. coli (AB 1157) as a model for living systems, demonstrated that PC acts as a cytostatic in air-free as well as in aerated media. However, it shows radiation protecting ability in the presence of N2O, where OH-radicals are the predominant reactants. Similar results were observed at pH=6.2. The experimental data contribute to a better understanding of the many-sided and frequently contradictory behavior of PC.

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