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Ultrastructural characteristics of macrophage transformation in foam cells in in vitro experiments

Nagornev, V.A.; Popov, A.V.; Pleskov, V.M.; Bobryshev, I.V.

Biulleten' Eksperimental'noi Biologii i Meditsiny 99(5): 617-619

1985

ISSN/ISBN: 0365-9615
PMID: 4005421
Document Number: 252660
Ultrastructural features of lipid vacuole formation in foam cells were studied in a mouse macrophage culture on the use of aggregated low density lipids (a-LDL) and fibroblast-modified LDL (fm-LDL). Modification of LDL properties is a factor which induces rapid transformation of macrophages to foam cells. Catabolism of a-LDL and fm-LDL and lipid vacuole formation is carried out in two ways: with and without involvement of lysosomes. In the former case membraneless lipid vacuoles are formed, in the latter one, lipid vacuoles surrounded by a membrane.

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