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Comparative study on antibacterial effects of huangqin-tang and its metabolites produced by intestinal flora

Yan, M.-z.; Zuo, F.; Song, H.-y.; Ye, W.-h.; Zhou, Z.-m.

Zhongguo Zhong Yao Za Zhi 28(3): 243-246

2003

ISSN/ISBN: 1001-5302
PMID: 15015311
Document Number: 562802
To compare the antibacterial effects of Huangqin-Tang with its metabolites produced by intestinal flora. The antibacterial tests in vitro and in vivo were performed by agar dilution method and lethal protection of animal respectively. Huangqin-Tang and its metabolites had antibacterial action on bacteria in vitro, however the antibacterial activity of metabolites of Huangqin-Tang on Salmomella, Dysentery bacillus and Proteus in vitro was stronger than Huangqin-Tang. The metabolites of Huangqin-Tang had protective effect on the animals infected by Staphylococcus aureus and Escherichia coli respectively from death, but Huangqin-Tang had no lethal protection action. The antibacterial effects of metabolites of Huangqin-Tang in vitro and in vivo are stronger than that of Huangqin-Tang, which shows that intestinal flora play a very important role in antibacterial effects of Huangqin-Tang.

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