A comparative study in cultured rat liver cells of the metabolism of different analogues and metabolites of a natural hepatocarcinogen: safrol
Janiaud, P.; Delaforge, M.; Levi, P.; Maume, B.F.; Padieu, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 170(5): 1035-1041
1976
ISSN/ISBN: 0037-9026 PMID: 139975 Document Number: 101507
Metabolism by sexed rat liver cell lines of safrole, a natural hepatocancerogen and of metabolites and analogs were studied and compared by gas chromatography-mass spectrometry. The epoxide-diol route was evidenced for safrole, isosafrole and eugenol as well as the induction of drug metabolizing enzymes by tested compounds.