The effect of prostaglandin F2 alpha and its analogues on progesterone, estradiol and androgen production by the cultured bovine luteal cells
Gregoraszczuk, E.L.; Wojtusiak, A.; Rózańska, A.
Folia Histochemica et Cytobiologica 26(4): 193-202
1988
ISSN/ISBN: 0239-8508 PMID: 3220142 Document Number: 318562
The effect of PGF2 alpha and its analogues on progesterone, estradiol and androgen production in cow corpus luteum in vitro was investigated. The cells derived from cow corpora lutea (CL) and collected in the early and middle luteal phases of the oestrus cycle were cultured as monolayers. The inhibitory effect was not apparent during the first 48 hr of culture, but appeared after this time and persisted through the remainder of the culture period. The direct luteolytic influence of PGF2 alpha was observed in the cultured cells and showed that this compound can act independently of the blood supply.