The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites
Ryan, A.J.; Bend, J.R.
Drug Metabolism and Disposition the Biological Fate of Chemicals 5(4): 363-367
1977
ISSN/ISBN: 0090-9556 PMID: 19215 Document Number: 110345
[Styrene is an environmental pollutant.] Isolated perfused rat livers rapidly metabolized 14C-styrene oxide. A large proportion of the administered radioactivity was excreted in the bile as a single compound that was identified as S-(1-phenyl-2-hydroxyethyl)glutathione by comparison with an authentic synthetic standard. The circulating perfusate was found to contain approximately equal amounts of styrene glycol, mandelic acid, and the glutathione derivative.