Identification of metabolites from salts of pyridine-2-thiol-1-oxide following intravenous and dermal adminstration to swine
Wedig, J.H.; Mitoma, C.; Howd, R.A.; Thomas, D.W.
Toxicology and Applied Pharmacology 43(2): 373-379
1978
ISSN/ISBN: 0041-008X PMID: 635924 Document Number: 134273
Mature female Yorkshire swine were given 14C-labeled zinc pyrithione (ZPT), sodium pyrithione (NPT) and the magnesium sulfate adduct of 2,2'-dithio-bis(pyridine-1-oxide) (MDS) i.v. and by dermal application. The urine from the i.v. study contained 1 major and 2 minor metabolites. Analyses of these by gas chromatography-mass spectrometry indicated that the major metabolite was the S-glucuronide of 2-mercaptopyridine-N-oxide and 1 of the minor metabolites was the S-glucuronide of 2-mercaptopyridine. The metabolic pattern after the dermal application was considerably different. Chromatographic evidence indicated that the major metabolites were 2,2'-pyridyldisulfide and 2-(pyridyl-N-oxide) sulfonic acid.