Decreased retention of fatty acid conjugated DDT metabolites in rats given injections of heparin, bile salts or lecithin
Leighty, E.G.
Research Communications in Chemical Pathology and Pharmacology 31(1): 69-76
1981
ISSN/ISBN: 0034-5164 PMID: 7255875 Document Number: 179207
Intravenous injections of solutions of heparin, bile salts or lecithin into rats previously intraperitoneally injected with 14C-DDT significantly removed fatty acid conjugated 14C-DDT metabolites retained in their livers and spleens. These 14C-DDT metabolites comprised greater than 90 percent of the radioactivity present in these organs 10 days after the animals were first injected with 14C-DDT. The conjugation of DDT metabolites to fatty acids thus appears to be a primary mechanism by which DDT is ultimately retained in animals and possibly humans. Heparin, bile salts or lecithin might be used as clearing agents for removing these conjugates.