Bile salt metabolism in intestinal tuberculosis increased glycine: taurine ratio of conjugated bile salts
Desai, H.G.; Zaveri, M.P.; Antia, F.P.
Indian Journal of Medical Research 63(12): 1767-1773
1975
ISSN/ISBN: 0019-5340 PMID: 1225835 Document Number: 86313
In 26 adult patients with intestinal tuberculosis, absorption tests and bile salt studies (cholate concentration, bile salt concentration, glycine:taurine ratio and TLC were performed. Steatorrhea was present in .apprx. 70% of patients while vitamin B12 and D-xylose malabsoportion were present in 79% and 58% of patients, respectively. The mean total bile salt and cholate concentration were significantly lower in patients with intestinal tuberculosis compared to those in control subjects. In most patients the values were above the critical micellar concentration. The glycine:taurine ratio was significantly higher in patients with intestinal tuberculosis compared to those in control subjects.