Recent progress of potential effects and mechanisms of chlorogenic acid and its intestinal metabolites on central nervous system diseases
Xing, L-na.; Zhou, M-mei.; Li, Y.; Shi, X-wen.; Jia, W.
Zhongguo Zhong Yao Za Zhi 40(6): 1044-1047
2015
ISSN/ISBN: 1001-5302 PMID: 26226742 Document Number: 683349
Chlorogenic acid displays several important roles in the therapeutic properties of many herbs, such as antioxidant activity, antibacterial, antiviral, scavenging free radicals and exciting central nervous system. Only about one-third of chlorogenic acid was absorbed in its prototype, therefore, its gut metabolites play a more important role in the therapeutic properties of chlorogenic acid. It is necessary to consider not only the bioactivities of chlorogenic acid but also its gut metabolites. This review focuses on the potential activities and mechanisms of chlorogenic acid and its gut metabolites on central nervous system diseases.