Effect of monensin on Mayaro virus replication in monkey kidney and Aedes albopictus cells
De Campos, R.M.; Ferreira, D.F.; Da Veiga, V.F.; Rebello, M.A.; Rebello, M.C.S.
Acta Virologica 47(2): 113-119
2003
ISSN/ISBN: 0001-723X PMID: 14524478 Document Number: 559069
The effect of a cationic ionophore, monensin, on the replication of Mayaro virus in monkey kidney TC7 and Aedes albopictus cells has been studied. Treatment of these cells with 1 micromol/l monensin during infection did not affect the virus protein synthesis but inhibited severely the virus replication. Electron microscopy of the cells infected with Mayaro virus and treated with monensin revealed that the morphogenesis of Mayaro virus was impaired in TC7 but not in A. albopictus cells.