Interferon action on Mayaro virus replication

Rebello, M.C.; Fonseca, M.E.; Marinho, J.O.; Rebello, M.A.; Rebello, M.C; Fonseca, M.E; Marinho, J.O; Rebello, M.A

Home

>

Node

>

Subnode

Interferon action on Mayaro virus replication

Rebello, M.C.; Fonseca, M.E.; Marinho, J.O.; Rebello, M.A.

Acta Virologica 37(4): 223-231

1993

ISSN/ISBN: 0001-723X

PMID: 7905236

Document Number: 407114

Treatment of TC7 cells with interferon (IFN) drastically reduced the yield of infectious Mayaro virus under experimental conditions such that virus attachment and penetration into the cells were not affected. In IFN-treated cells, synthesis of Mayaro virus proteins was inhibited and cellular protein synthesis was restored. This suggests that IFN also interferes with Mayaro virus morphogenesis and inhibits the release of virions from cells.