Effects of interferon alpha on murine cytomegalovirus replication
Martinotti, M.G.; Gribaudo, G.; Gariglio, M.; Angeretti, A.; Cavallo, G.; Landolfo, S.
Microbiologica 15(2): 183-186
1992
ISSN/ISBN: 0391-5352 PMID: 1376391 Document Number: 399867
The present study examined the protective effect of IFN-.alpha. against mouse cytomegalovirus (MCMV) infection in embryo fibroblasts (MEF) of genetically resistant (C3H/H3J) and susceptible (C57BL/6) mouse strains. At a M.O.I. of 1 IFN-.alpha. was protective in C3H/HeJ-MEF but not in C57BL/6-MEF. Dot-blot analysis during MCMV replication in C3H/HeJ-MEF showed that IFN-.alpha. pretreatment reduced the steady state level of immediate early and late mRNAS but partially reduced early gene expression.
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