Enhanced replication of murine cytomegalovirus in murine leukemic lymphocytes
Pottathil, R.; Pottathil, I.R.; Cheung, K.S.; Lang, D.J.
Cancer Research 46(1): 124-126
1986
ISSN/ISBN: 0008-5472 PMID: 2998605 Document Number: 286158
Replication in vitro of murine cytomegalovirus was found to be enhanced in lymphoid cells from leukemic (AKR/J) mice as compared with similar cells from nonleukemic animals. Prolonged productive murine cytomegalovirus infection in lymphoid organs in vivo was demonstrable only in leukemic AKR/J mice. Latent nonproductive murine cytomegalovirus infection established in young nonleukemic AKR/J mice was invariably reactivated and expressed in salivary glands and lymphoid organs after these animals became leukemic.