Effect of high temperature on Aedes albopictus cells infected with Mayaro virus
Carvalho, M.G.; Rebello, M.A.; Mezencio, J.M.
Brazilian Journal of Medical and Biological Research 20(6): 857-860
1987
ISSN/ISBN: 0100-879X PMID: 2843253 Document Number: 293332
The multiplication of Mayaro virus in Aedes albopictus cells was drastically inhibited after incubation at 37 degrees C. The effect of short-term exposure of infected cells to high temperatures (heat shock) produced a preferential translation of the heat shock messengers when compared to the viral mRNAs. When cells were shifted back to 28 degrees C (the optimum growth temperature for A. albopictus cells), preferential translation of viral mRNA occurred. Although the infected cells were programmed for preferential translation of viral messengers, the thermal treatment was able to shift the translational machinery towards synthesis of heat shock proteins.