The effect of oil as a dietary component on in vitro dissolution of an acid-labile drug
Al-Behaisi, S.; Antal, I.; Morovján, G.; Marton, S.; Klebovich, I.
Die Pharmazie 58(7): 502-503
2003
ISSN/ISBN: 0031-7144 PMID: 12894756 Document Number: 555574
The non-benzodiazepine-like anxiolytic agent deramiclane fumarate (EGIA-3886) was used to demonstrate that the presence of high oil/fat content in dissolution media serves as a barrier against accelerated drug degradation in acidic media.
Document emailed within 1 workday
Related Documents
Northern, R.E.; Lach, J.L.; Fincher, J.H. 1973: Dissolution-dialysis method of assessing in vitro drug availability of prednisolone tablets American Journal of Hospital Pharmacy 30(7): 622-627Pessina, A.; Neri, M.G.; Muschiato, A. 1982: Effect of heat-labile enterotoxin(LT) produced by Escherichia coli on in vitro cell proliferation Experientia 38(9): 1056-1057
Sidorova, L.N.; Baĭkov, V.G.; Bessonov, V.V.; Skobel'skaia, Z.G. 2007: Effect of dietary fibers on preservation of lipid component in flour confectionery Voprosy Pitaniia 76(3): 78-81
Torrado, S.; Torrado, S.; Agis, A.; Jimenez, M.E.; Cadórniga, R. 1995: Effect of dissolution profile and (-)-alpha-bisabolol on the gastrotoxicity of acetylsalicylic acid Die Pharmazie 50(2): 141-143
Mcgregor, L.; Renaud, S. 1978: Effect of dietary linoleic acid deficiency on platelet aggregation and phospholipid fatty acid of rats Thrombosis Research 12(5): 921-927
El-Maghraby, G.M.; Alomrani, A.H. 2011: Effect of binary and ternary solid dispersions on the in vitro dissolution and in-situ rabbit intestinal absorption of gliclazide Pakistan Journal of Pharmaceutical Sciences 24(4): 459-468
Mandon, E.C.; de Gómez Dumm, I.N.; Brenner, R.R. 1986: Effect of dietary columbinic acid on the fatty acid composition and physical membrane properties of different tissues of EFA-deficient rats Archivos Latinoamericanos de Nutricion 36(3): 401-414
Delucchi Zunino, M.; Gómez Sandoval, V.; Aránguiz Burgos, T.; Jaramillo Mena, V.; Bravo Figueroa, J.; Cordero Rodríguez, M. 1985: Trituration kinetics and its effect on the granulometric properties and the dissolution rate of a poorly soluble drug: sulfadiazine Il Farmaco; Edizione Pratica 40(1): 22-32
Bećirević-Laćan, M.; Filipović-Grcić, J. 2000: Effect of hydroxypropyl-beta-cyclodextrin on hydrocortisone dissolution from films intended for ocular drug delivery Die Pharmazie 55(7): 518-520
Selmeczi, B.; Kedvessy, G.; Nagy, G.; Pintyéné Hódi, K.; Tencova, A.; Kiszeleva, G. 1981: Influence of the technological procedure and additives on the dissolution rate and absorption of active ingredients. I. Physical properties of acetylsalicylic acid tablets and of the dissolution rate of the active ingredient Acta Pharmaceutica Hungarica 51(5): 222-227
Zhang, L.; He, Y.; Zhang, F.; Tian, T.; Song, W.; Wan, H. 2012: Effect of glycyrrhizic acid on growth of Streptococcus mutans under acid environment in vitro Hua Xi Kou Qiang Yi Xue Za Zhi 30(6): 594-597; 602
Klein, G.; Wottawa, A.; Altmann, H.; Eberl, R. 1974: Effect of metiazinic acid, ketoprofen, oxyphenbutazone, and flufenamic acid on the enzymes of DNA synthesis and repair in the in vitro experiment Arzneimittel-Forschung 24(12): 1975-1978
Kabara, J.J. 1987: Effect of dietary fats and proteins on drug metabolism Journal of Environmental Pathology Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer 7(3): 1-9
Campbell, T.C.; Hayes, J.R. 1976: The effect of quantity and quality of dietary protein on drug metabolism Federation Proceedings 35(13): 2470-2474
Shull, L.R.; Buckmaster, G.W.; Cheeke, P.R. 1979: Effect of dietary selenium status on in vitro hepatic mixed-function oxidase enzymes of rats Journal of Environmental Pathology and Toxicology 2(4): 1127-1138
el Ashry, A.; Heagerty, A.M.; Ollerenshaw, J.D.; Thurston, H. 1989: The effect of dietary linoleic acid on blood pressure and erythrocyte sodium transport Journal of Human Hypertension 3(1): 9-15
Szymczak, J.; Własikowa, R.; Biernat, J.; Iwanicka, Z.; Koziorowski, L.C. 1982: Effect of dietary fats on the plasma fatty acid content in diabetic children Przeglad Lekarski 39(7): 505-508
Yano, Y. 1992: Effect of dietary supplementation with eicosapentaenoic acid on surgically induced endometriosis in the rabbit Nihon Sanka Fujinka Gakkai Zasshi 44(3): 282-288
Ormrod, I.H.; Thomas, P.C.; Wheelock, J.V. 1980: The effect of dietary inclusions of tallow on the citric acid and soluble calcium content of cow's milk Proceedings of the Nutrition Society 39(2): 33A
Hogan, M.L.; Shamsuddin, A.M. 1984: Large intestinal carcinogenesis. I. Promotional effect of dietary fatty acid isomers in the rat model Journal of the National Cancer Institute 73(6): 1293-1296