Clinical value of the antioxidative activity of blood serum and lacrimal fluid in endogenous uveitis in children
Katargina, L.A.; Sidorova, T.V.; Chesnokova, N.B.; Kuznetsova, T.P.
Vestnik Oftalmologii 119(2): 20-21
2003
ISSN/ISBN: 0042-465X PMID: 13678002 Document Number: 553014
The method of chemiluminescence in the system of hemoglobin-peroxide hydrogen-luminal was made use of to study the antioxidant activity (AOA) of lacrimal fluid and blood serum in 20 children with endogenous uveitis. As uveitis aggravated, there is observed a reduced AOA both in lacrimal fluid and blood serum. As the inflammatory process is arrested, AOA begins to go down gradually; moreover, it approaches the values in the control group. The correlation between the lacrimal fluid AOA and the blood serum AOA was calculated and analyzed for each eye for the moment of examination. The low values of the coefficient were found for the constantly relapsing uveitis, while the high values were typical for the initial remission phase. A study of the correlation between the blood serum AOA and the lacrimal fluid AOA showed a low correlation coefficient (r = 0.3) during the uveitis aggravation period and its increase during the remission period (r = 0.7). The obtained data are indicative of that the free-radical processes are involved in the pathogenesis of endogenous uveitis; they also show that it is advisable to study the lacrimal-fluid and blood-serum AOAs in order to forecast the above disease and to choose an optimal therapy methods.