A comparative study of the pharmacokinetics of quinidine
Neff, C.A.; Davis, L.E.; Baggot, J.D.
American Journal of Veterinary Research 33(7): 1521-1525
1972
ISSN/ISBN: 0002-9645 PMID: 5039523 Document Number: 55237
The kinetics and concentrations of quinidine were determined in ponies, goats, pigs, dogs, and cats following intravenous administration. Plasma half-life values varied from 0.85 hours in goats to 5.59 hours in dogs. Quinidine attained distribution equilibrium very rapidly and was sequestered in the tissues. Apparent specific volumes of distribution ranged from 1.25 l/kg in pigs to 6.32 in ponies. The drug was extensively bound to plasma proteins, with values ranging from 77% in caprine plasma to 98% in porcine plasma.