Comparative analysis of the pharmacokinetics of N1-unsubstituted derivatives of 1,4-benzodiazepine
Andronati, S.A.; Golovenko, N.I.; Stankevich, E.A.; Zin'kovskiĭ, V.G.; Iakubovskaia, L.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(2): 180-182
1986
ISSN/ISBN: 0365-9615 PMID: 3947735 Document Number: 272374
Parameters of 14C-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2 and its main metabolite distribution in the blood plasma and brain of mice were compared with phenazepam and nordiazepam distribution. Constant ratio of blood plasma 14C-7-bromo-5-phenyl-1,2-dihydro-3A-1,4-benzodiazepine-2, its 3-hydroxy metabolite and other derivatives' level to brain level was noted vs their changing content in the mentioned test objects. Characteristic peculiarities of the distribution of initial 1,4-benzodiazepines and their metabolites and its predictive value are discussed.