Effect of 1,5-benzodiazepine derivatives on the electrical activity of neurons of the Helix albescens Rossm
Koreniuk, I.I.; Iepishkin, I.V.; Hamma, T.V.; Khusainov, D.R.
Fiziolohichnyi Zhurnal 57(3): 49-58
2011
ISSN/ISBN: 2522-9028 PMID: 21870518 Document Number: 653272
Using a standard technique for intracellular recording of potentials, we investigated the influence of two new derivatives of 1,5-benzodiazepine-2-one on the electrical activity of neurons of the Helix albescens Rossm. These substances possess neurotropic properties, the effects were concentration dependent in the concentration range 10(-6) M -10(-2) and did not depend on the type of neurons. We defined the threshold, optimum and toxic concentrations for the compounds investigared. Analysis of the total ion current showed that the compounds reduce the rate of inward Na+- and Ca2+ currents and of outward K+-currents.