Mechanisms of action of nonachlazine
Oganesian, N.M.; Oganesian, S.S.; Varosian, M.A.; Bagramian, I.G.; Barinian, S.B.
Farmakologiia i Toksikologiia 44(3): 283-287
1981
ISSN/ISBN: 0014-8318 PMID: 7286184 Document Number: 5487
In animals with a ligated anterior descending left coronary artery, a single administration of nonaclazine (5 mg/kg bw) leads to a marked increase in the coronary blood flow and to an improvement in cardiovascular system function. Administration of nonachlazin for 7 days helps normalize the electrophysiological and hemodynamic characteristics and produces a beneficial effect on the myocardial blood flow and contractility. Interaction of nonaclazine with adrenergic receptors does not appear to have any decisive significance in the drug action mode.
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