Effect of nonachlazine on cerebral circulation
Miller, L.G.; Usov, L.A.
Farmakologiia i Toksikologiia 42(4): 368-371
1979
ISSN/ISBN: 0014-8318 PMID: 477956 Document Number: 139993
It has been shown in acute experiments on anesthetized cats that nonachlazine in a dose of 2.5 mg/kg produces a short-term decrease followed by more prolonged elevation of the tone of cerebral vessels, lower extremities and systemic arterial blood pressure. Previous blocking of alpha- and beta-adrenoreceptors decreases or abolishes the development of the above effects. In a dose of 5 mg/kg nonachlazine produces no rise in the tone of intracranial vessels, but increases local and common cerebral blood flow. An increase in PO2 in the brain cortex correlates well with a rise in the blood flow.