Mechanisms of the hemodynamic effects of nonachlazine in ischemic heart disease patients
Zaslavskaia, R.M.; Zolotaia, R.D.; Olevskiĭ, I.K.; Duda, S.G.; Vilkovyskiĭ, F.A.
Farmakologiia i Toksikologiia 49(6): 73-77
1986
ISSN/ISBN: 0014-8318 PMID: 3817152 Document Number: 278303
During course therapy with nonachlazine of patients with ischemic heart disease, stable angina pectoris a negative inotropic effect of the drug in persons with eukinetic and in particular hyperkinetic type of hemodynamics was revealed. Enhancement of beta-adrenoblocking effect of nonachlazine with an increase of its daily dose was found. Nonachlazine effect on hemodynamic parameters was shown to be mediated through adrenoreactive structures.
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