Determination of cinnabar in zijinhong capsules by high performance liquid chromatography
Kong, A.-Y.; Jiang, X.-P.; Wei, L.-P.
Se Pu 20(5): 449-451
2002
ISSN/ISBN: 1000-8713 PMID: 16358700 Document Number: 548677
A high performance liquid chromatographic method was established for the determination of cinnabar in Zijinhong capsules using diethyldithiocarbamate (DEDTC) chelate. A Waters X-Terra C18 column was used with a mixture of methanol-0.01 mol/L Na2HPO4 (pH 7.5) (containing 0.01% DEDTC) (73:27, V/V) as the mobile phase and a detector set at 270 nm. The calibration curve was linear (r = 0. 999 6) in the range of 10.1 mg/L - 100.9 mg/L of Hg2+. The recoveries were 97.0% - 100.8% with RSDs of 1.8% - 2.3%.