Spectrophotometric determination of phenylephrine hydrochloride in pharmaceuticals by flow injection analysis exploiting the reaction with potassium ferricyanide and 4-aminoantipyrine
Rocha, Jé.R.C.; Galhardo, C.X.; Natividade, M.Auxiliadora.E.; Masini, J.C.
Journal - Association of Official Analytical Chemists 85(4): 875-878
2002
ISSN/ISBN: 0004-5756 PMID: 12180681 Document Number: 547891
This paper presents a method for the determination of phenylephrine hydrochloride in pharmaceuticals by spectrophotometric flow injection analysis exploiting the reaction with potassium ferricyanide and 4-aminoantipyrine, which leads to the formation of a condensation product with strong absorptivity at 500 nm. The linear dynamic range was between 0.95 and 9 mg/L, with a limit of detection of 0.2 mg/L and a sampling throughput of 120 samples per hour. The method was applied to eyewashes and nasal decongestant liquid medicines.