Spectrophotometric determination of piperazine and its salts in pharmaceuticals
Abou-Ouf, A.M.; Walash, M.I.; Rizk, M.S.; Ibrahim, F.A.
Journal - Association of Official Analytical Chemists 62(5): 1138-1140
1979
ISSN/ISBN: 0004-5756 PMID: 528460 Document Number: 144864
A spectrophotometric determination of piperazine and some of its salts is described. The method depends on the UV measurement of the N-nitroso derivatives formed by the interaction of piperazine with nitrous acid. The chromophore is developed by heating the reaction mixture at 80 degrees C for 15 min, at pH 2.3--2.6. Beer's law is obeyed in the range 1--15 micrograms/mL.