Densitometric determination of impurities in pharmaceuticals. Part VI. Determination of 4,4-bis[4- (p-chlorophenyl) - 4-hydroxypiperidino]butyrophenone in haloperidol
Krzek, J.; Maślanka, A.
Acta Poloniae Pharmaceutica 57(1): 23-26
2000
ISSN/ISBN: 0001-6837 PMID: 10846793 Document Number: 516987
A chromatographic and densitometic method for identification and quantitative determination of 4,4-bis[4-(p-chlorophenyl)-4-hydroxypiperidino]butyrophenone as an impurity in haloperidol pharmaceutical has been developed. The HPTLC plates and chloroform-methanol-ammonium hydroxide 25% (90:9:1) were used for chromatographic separation as stationary and mobile phases respectively. Detection has been carried out in UV at lambda = 350 nm. The determination could be made directly without preliminary component separation by extraction. Based on the statistical analysis of obtained results, it was found that the new method is accurate and repeatable.