Determination of the chemical structure of potential organic impurities occurring in the drug substance opipramol
Luboch, E.; Wagner-Wysiecka, E.; Jamrógiewicz, M.; Szczygelska-Tao, J.; Magiełka, S.; Biernat, J.F.
Die Pharmazie 65(4): 239-244
2010
ISSN/ISBN: 0031-7144 PMID: 20432617 Document Number: 643454
The tricyclic antipsychotic and antidepressant drug opipramol (opipramole) was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were established by 1H NMR, MS and FTIR and further confirmed by comparison with commercially available products or with products obtained by independent synthesis, and in one case additionally by X-ray structure analysis.