Spectrophotometric analysis of raloxifene hydrochloride in pure and pharmaceutical formulations
Dharuman, J.; Ravichandran, V.; Thirumoorthy, N.; Dharamsi, A.
Die Pharmazie 59(9): 720-721
2004
ISSN/ISBN: 0031-7144 PMID: 15497756 Document Number: 577028
Two simple and sensitive spectrophotometric methods (A and B) for the determination of raloxifene hydrochloride in bulk samples and pharmaceutical formulations are described. Method A is based on the oxidation of the drug with ferric chloride and coupling with potassium ferric cyanide. Method B is based on reduction of the drug with Fehling's reagent. Bluish green color formed in method A absorbs at 735 nm and brown color produced in method B absorbs at 430 nm.
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